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Dataset 2: Gene ontology (GO) term enrichment in hemin-induced genes (Gene Ontology Resource) Dataset 3: Transcription factor target gene enrichment among differentially expressed genes detected with PRO-seq (Enrichr) Dataset 4: Motif occurences on hemin-induced enhancers (MEME-ChIP) Supplementary figure legends Acknowledgements We thank the members of the Vartiainen, Sistonen and Vihervaara laboratories for valuable discussions during the manuscript preparation

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